Multiparticulate Chitosan-Dispersed System for Drug Delivery

Multiparticulate chitosan-dispersed system for drug delivery.

A multiparticulate chitosan-dispersed system (CDS), which is composed of the drug reservoir and the drug release-regulating layer, was developed for drug delivery. The drug release-regulating layer is a mixture of water-insoluble polymer and chitosan powder. The drug is released from CDS pellets in all regions of the gastrointestinal tract (from the stomach to the colon). CDS pellets containing...

Multiparticulate Carriers for Controlled Oral Drug Delivery

An overview on multiparticulate drug delivery system: Pellets

Pellets can be defined as small, free flowing, spherical or semi-spherical solid units, typically from about 0.5 mm to 1.5 mm, and intended usually for oral administration, manufactured by the agglomerates of fine powders or granules of bulk drugs and excipients using appropriate processing equipment. Pellets can be prepared by many methods, the compaction and drug-layering being the most widel...

An in vitro evaluation of a chitosan-containing multiparticulate system for macromolecule delivery to the colon.

A multiparticulate system of chitosan hydrogel beads has been investigated for colon-specific delivery of macromolecules using fluorescein isothiocyanate-labeled bovine serum albumin as a model protein. The hydrogel bead was formed by polyelectrolyte complexation of chitosan with its counterion, tripolyphosphate (TPP). The protein release experiments were carried out in vitro under different co...

Phytosome: Drug Delivery System for Polyphenolic Phytoconstituents

      Several plant extracts and phytoconstituents, despite having excellent bioactivity in vitro, demonstrate less or no in vivo actions due to their poor lipid solubility or improper molecular size or destruction in gut. Drug delivery system for polyphenolic phytoconstituents (phytosomes) was prepared by complexing polyphenolic phytoconstituents with phospholipid mainly phosphatidylcholine wh...